SciPy 2021, the 20th annual Scientific Computing with Python conference, will be a virtual conference held July 12-18, 2021. The annual SciPy Conference brings together attendees from industry, academia, and government to showcase their latest projects, learn from skilled users and developers, and collaborate on code development. The full program will consist of 2 days tutorials (July 12-13), 3 days of talks (July 14-16), and 2 days of developer sprints (July 17-18).